BDBM50138406 3TC Triphosphate::CHEMBL1230::LAMIVUDINE::Lamivudine triphosphate::[(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl tetrahydrogen triphosphate::[[[5-(4-amino-2-oxo-1H-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid

SMILES: C1[C@H](O[C@H](S1)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=CC(=NC2=O)N

InChI Key: InChIKey=YLEQMGZZMCJKCN-UHFFFAOYSA-N

Data: 1 KI  1 IC50  8 Kd

PDB links: 8 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50138406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase protein (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase protein (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase protein (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase protein (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA polymerase subunit gamma-1 (Human)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus type 1)	BDBM50138406 ([(2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-o...) Show SMILES Show InChI	GoogleScholar	UniChem		188	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair