BDBM50138783 4-((S)-Amino-carboxy-methyl)-phthalic acid::4-[amino(carboxy)methyl]phthalic acid::CHEMBL143210

SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O

InChI Key InChIKey=IJVMOGKBEVRBPP-ZETCQYMHSA-N

Data  15 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50138783   

TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50: >1.00E+5nMAssay Description:Metabotropic glutamate receptor 7 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  31nMAssay Description:Activation of human metabotropic glutamate 8 receptor expressed in golden hamster AV12-664 cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50: >1.00E+5nMAssay Description:Metabotropic glutamate receptor 5 agonist activity as basal [3H]- IP formation in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.60E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  31nMAssay Description:Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.20E+4nMAssay Description:Metabotropic glutamate receptor 1 agonist activity as basal [3H]- IP formation in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50: >1.00E+5nMAssay Description:Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  8.80E+3nMAssay Description:Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  8.80E+3nMAssay Description:Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  1.96E+3nMAssay Description:Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  44nMAssay Description:Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.20E+3nMAssay Description:Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as increase in intracellular calcium...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50: >1.00E+5nMAssay Description:Metabotropic glutamate receptor 2 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed