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BDBM50139601 1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea::4-(4-(3-(4-bromo-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide::4-{4-[3-(4-Bromo-3-trifluoromethyl-phenyl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide::CHEMBL350747

SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1

InChI Key: InChIKey=WINHEDROZCCEOE-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50139601   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-RAF


(Homo sapiens (human))
BDBM50139601
PNG
(1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(met...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16BrF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibitory activity against human Raf-1 kinase


Bioorg Med Chem Lett 14: 783-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.041
BindingDB Entry DOI: 10.7270/Q2TM79JT
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50139601
PNG
(1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(met...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16BrF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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PC sid
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Article
PubMed
n/an/a 6n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Raf1 kinase


Bioorg Med Chem Lett 18: 2346-50 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.068
BindingDB Entry DOI: 10.7270/Q25X29S8
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50139601
PNG
(1-(4-bromo-3-(trifluoromethyl)phenyl)-3-(4-(2-(met...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16BrF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of B-Raf1 (unknown origin)


Eur J Med Chem 44: 1240-9 (2009)


Article DOI: 10.1016/j.ejmech.2008.09.016
BindingDB Entry DOI: 10.7270/Q28G8KJ5
More data for this
Ligand-Target Pair