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BDBM50140194 CHEMBL3752074

SMILES: COc1cc(NC(=O)Nc2ccccn2)cc(-c2cccnc2)c1OC

InChI Key: InChIKey=GCJNDMDPMOVHTQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50140194   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50140194
PNG
(CHEMBL3752074)
Show SMILES COc1cc(NC(=O)Nc2ccccn2)cc(-c2cccnc2)c1OC
Show InChI InChI=1S/C19H18N4O3/c1-25-16-11-14(22-19(24)23-17-7-3-4-9-21-17)10-15(18(16)26-2)13-6-5-8-20-12-13/h3-12H,1-2H3,(H2,21,22,23,24)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 69n/an/an/an/an/an/a



The First Affiliated Hospital of Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assay


Bioorg Med Chem 24: 750-8 (2016)


Article DOI: 10.1016/j.bmc.2015.12.038
BindingDB Entry DOI: 10.7270/Q2FQ9ZFQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50140194
PNG
(CHEMBL3752074)
Show SMILES COc1cc(NC(=O)Nc2ccccn2)cc(-c2cccnc2)c1OC
Show InChI InChI=1S/C19H18N4O3/c1-25-16-11-14(22-19(24)23-17-7-3-4-9-21-17)10-15(18(16)26-2)13-6-5-8-20-12-13/h3-12H,1-2H3,(H2,21,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 49n/an/an/an/an/an/a



The First Affiliated Hospital of Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of EGFR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assay


Bioorg Med Chem 24: 750-8 (2016)


Article DOI: 10.1016/j.bmc.2015.12.038
BindingDB Entry DOI: 10.7270/Q2FQ9ZFQ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50140194
PNG
(CHEMBL3752074)
Show SMILES COc1cc(NC(=O)Nc2ccccn2)cc(-c2cccnc2)c1OC
Show InChI InChI=1S/C19H18N4O3/c1-25-16-11-14(22-19(24)23-17-7-3-4-9-21-17)10-15(18(16)26-2)13-6-5-8-20-12-13/h3-12H,1-2H3,(H2,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



The First Affiliated Hospital of Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of KDR (unknown origin) incubated for 1 hr assessed as luminescence changes using ATP by ADP-Glo Kinase assay


Bioorg Med Chem 24: 750-8 (2016)


Article DOI: 10.1016/j.bmc.2015.12.038
BindingDB Entry DOI: 10.7270/Q2FQ9ZFQ
More data for this
Ligand-Target Pair