BDBM50140367 2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide::CHEMBL20604

SMILES Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O

InChI Key InChIKey=FXGWYXPHUQWSQF-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50140367   

TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50:  9nMAssay Description:Binding affinity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against tissue type plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Rattus norvegicus)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against PlasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50140367(2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration of compound was determined against activated protein C (aPC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed