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BDBM50140475 (E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4-yl]-3-phenyl-acrylamide::CHEMBL265065

SMILES: CC(=O)N1CCc2ccc(cc12)N(C1CCN(CCC2CCCC2)CC1)C(=O)\C=C\c1ccccc1

InChI Key: InChIKey=JKRGNGFKHLMMMZ-SDNWHVSQSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50140475   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50140475
PNG
((E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-N-[1-(2...)
Show SMILES CC(=O)N1CCc2ccc(cc12)N(C1CCN(CCC2CCCC2)CC1)C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C31H39N3O2/c1-24(35)33-22-16-27-12-13-29(23-30(27)33)34(31(36)14-11-25-7-3-2-4-8-25)28-17-20-32(21-18-28)19-15-26-9-5-6-10-26/h2-4,7-8,11-14,23,26,28H,5-6,9-10,15-22H2,1H3/b14-11+
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 800n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-PYY from human NPYY2 receptor


Bioorg Med Chem Lett 24: 430-41 (2014)


Article DOI: 10.1016/j.bmcl.2013.11.061
BindingDB Entry DOI: 10.7270/Q2H133HQ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))
BDBM50140475
PNG
((E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-N-[1-(2...)
Show SMILES CC(=O)N1CCc2ccc(cc12)N(C1CCN(CCC2CCCC2)CC1)C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C31H39N3O2/c1-24(35)33-22-16-27-12-13-29(23-30(27)33)34(31(36)14-11-25-7-3-2-4-8-25)28-17-20-32(21-18-28)19-15-26-9-5-6-10-26/h2-4,7-8,11-14,23,26,28H,5-6,9-10,15-22H2,1H3/b14-11+
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Binding affinity towards the NPY Y2 receptor


Bioorg Med Chem Lett 14: 1239-42 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.057
BindingDB Entry DOI: 10.7270/Q2M044VK
More data for this
Ligand-Target Pair