BDBM50142025 5-Bromo-3-(5-bromo-6-hydroxy-2'-methoxy-biphenyl-3-ylmethylene)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one::CHEMBL176857

SMILES COc1ccccc1-c1cc(\C=C2/C(=O)Nc3ncc(Br)cc23)cc(Br)c1O

InChI Key InChIKey=RIJBDOXTEPVDPJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50142025   

TargetHigh affinity nerve growth factor receptor(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50142025(5-Bromo-3-(5-bromo-6-hydroxy-2'-methoxy-biphenyl-3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of GST-fused TrkA (unknown origin) expressed in SF9 cells using H2N-RRRAAAEEIYGEINH2 peptide as substrate preincubated with ATP and Mg and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50142025(5-Bromo-3-(5-bromo-6-hydroxy-2'-methoxy-biphenyl-3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142025(5-Bromo-3-(5-bromo-6-hydroxy-2'-methoxy-biphenyl-3...)
Affinity DataIC50: 700nMAssay Description:Inhibition of c-Raf1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142025(5-Bromo-3-(5-bromo-6-hydroxy-2'-methoxy-biphenyl-3...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed