BDBM50142759 (R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethyl)phenyl)methanesulfonamide::CHEMBL412885::N-(4-tert-butylbenzyl)-N'-{(1R)-1-[4-(methylsulfonylamino)phenyl]ethyl}thiourea::N-(4-{(R)-1-[3-(4-tert-Butyl-benzyl)-thioureido]-ethyl}-phenyl)-methanesulfonamide

SMILES C[C@@H](NC(=S)NCc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)cc1

InChI Key InChIKey=MRGDOZGZFFCDRJ-OAHLLOKOSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50142759   

TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Sookmyung Women'S University

Curated by ChEMBL
LigandPNGBDBM50142759((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as intracellular 45Ca2+ influx by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Sookmyung Women'S University

Curated by ChEMBL
LigandPNGBDBM50142759((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at TRPV1 in neonatal rat DRG neurons assessed as inhibition of capsaicin-induced intracellular calcium after 10 mins in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Sookmyung Women'S University

Curated by ChEMBL
LigandPNGBDBM50142759((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRPV1 in neonatal rat DRG neurons assessed as increase in calcium influx after 10 mins in presence of 45Ca2+ by Beckman CP scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Sookmyung Women'S University

Curated by ChEMBL
LigandPNGBDBM50142759((R)-N-(4-(1-(3-(4-tert-butylbenzyl)thioureido)ethy...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated intracellular 45Ca2+ influx by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed