BDBM50142887 1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[3,4-d]pyrimidine::1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine::1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine::4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine::AG-1879::CHEMBL406845::PP2::US10544104, Compound 146::US10688093, Compound PP2 (Pfizer)::US11701353, PP2 (Pfizer)::US9765037, Compound 146::cid_4878

SMILES: CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc12

InChI Key: InChIKey=PBBRWFOVCUAONR-UHFFFAOYSA-N

Data: 8 KI  28 IC50  3 Kd  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 66 hits for monomerid = 50142887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase HCK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform delta (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase LCK (Mouse)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
60S ribosomal protein L19-A (Baker's yeast)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vacuolar aminopeptidase 1 (Baker's yeast)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.82E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase CSK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	500	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	36.6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 3 (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Chicken)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	296	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50142887 (1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair