BDBM50143127 3-(4-Fluoro-phenyl)-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazine::CHEMBL292462

SMILES Fc1ccc(cc1)-c1nnc2c3ccccc3c(OCc3ccccn3)nn12

InChI Key InChIKey=OKGJPMZATLJSGV-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143127   

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143127(3-(4-Fluoro-phenyl)-6-(pyridin-2-ylmethoxy)-[1,2,4...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143127(3-(4-Fluoro-phenyl)-6-(pyridin-2-ylmethoxy)-[1,2,4...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for human GABA-A receptor alpha3-beta3-gamma2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143127(3-(4-Fluoro-phenyl)-6-(pyridin-2-ylmethoxy)-[1,2,4...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50143127(3-(4-Fluoro-phenyl)-6-(pyridin-2-ylmethoxy)-[1,2,4...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits in L(tk-) cellsMore data for this Ligand-Target Pair
Target InfoGoogleScholar
In DepthDetails ArticlePubMed