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BDBM50143158 CHEMBL3758228

SMILES: Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2nccn2C)cc1Cl

InChI Key: InChIKey=OWDJNJLAMWJGMX-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50143158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143158
PNG
(CHEMBL3758228)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2nccn2C)cc1Cl
Show InChI InChI=1S/C20H15ClN4O3/c1-11-4-3-5-13-16(11)20(28)25(19(13)27)15-7-6-12(10-14(15)21)23-18(26)17-22-8-9-24(17)2/h3-10H,1-2H3,(H,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50143158
PNG
(CHEMBL3758228)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2nccn2C)cc1Cl
Show InChI InChI=1S/C20H15ClN4O3/c1-11-4-3-5-13-16(11)20(28)25(19(13)27)15-7-6-12(10-14(15)21)23-18(26)17-22-8-9-24(17)2/h3-10H,1-2H3,(H,23,26)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 506n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143158
PNG
(CHEMBL3758228)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2nccn2C)cc1Cl
Show InChI InChI=1S/C20H15ClN4O3/c1-11-4-3-5-13-16(11)20(28)25(19(13)27)15-7-6-12(10-14(15)21)23-18(26)17-22-8-9-24(17)2/h3-10H,1-2H3,(H,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair