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BDBM50144639 3-((R)-2-Amino-2-phenyl-ethyl)-1-benzyl-5-(2-fluoro-phenyl)-6-methyl-1H-pyrimidine-2,4-dione; TFA::CHEMBL433302

SMILES: Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1ccccc1

InChI Key: InChIKey=ZDCNRZJGAXIEDG-QHCPKHFHSA-N

Data: 1 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50144639   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin releasing hormone 1 (GnRHR1)


(Homo sapiens (Human))
BDBM50144639
PNG
(3-((R)-2-Amino-2-phenyl-ethyl)-1-benzyl-5-(2-fluor...)
Show SMILES Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1ccccc1
Show InChI InChI=1S/C26H24FN3O2/c1-18-24(21-14-8-9-15-22(21)27)25(31)30(17-23(28)20-12-6-3-7-13-20)26(32)29(18)16-19-10-4-2-5-11-19/h2-15,23H,16-17,28H2,1H3/t23-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
57n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc

Curated by ChEMBL


Assay Description
Binding affinity towards human gonadotropin-releasing hormone receptor expressed in HEK293 cells using des-Gly10-[125I]Tyr,5 DLeu,6 NMeLeu,7 Pro9-NEt...


Bioorg Med Chem Lett 14: 2269-74 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.004
BindingDB Entry DOI: 10.7270/Q2736QCQ
More data for this
Ligand-Target Pair