BDBM50144862 6-methyl-2-pyridyl 6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03,7]pentadeca-2(10),3,5,8-tetraen-9-yl ether::6-methyl-2-pyridyl[6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03,7]pentadeca-2(10),3,5,8-tetraen-9-yloxy]methane::CHEMBL68712
SMILES Cc1cccc(COc2nn3c(nnc3c3C4CCC(CC4)c23)-c2ccccc2)n1
InChI Key InChIKey=OFFQUPKDTOZERU-UHFFFAOYSA-N
Data 12 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50144862
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha5-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity towards human alpha5-beta3-gamma2 GABA-A receptor using [3H]-Ro-15-1788 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 23.7nMAssay Description:Binding affinity towards human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 using [3H]-Ro-15-1788 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha3-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 36nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric acid A receptor alpha2-beta3-gamma2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 44.5nMAssay Description:Binding affinity towards human gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 using [3H]-Ro-15-1788 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 46nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha2-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 122nMAssay Description:Binding affinity towards human alpha1-beta3-gamma2 GABA-A receptor using [3H]-Ro-15-1788 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
Target InfoGoogleScholar
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 subtype expressed in L (tk-) cellsMore data for this Ligand-Target Pair
Target InfoGoogleScholar
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp And Dohme Research Laboratories
Curated by ChEMBL
Affinity DataKi: 170nMAssay Description:Displacement of [3H]-Ro- 15-1788 from human GABA-A alpha1-beta3-gamma2 receptor subunits expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Target InfoGoogleScholar