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BDBM50145403 CHEMBL3764323

SMILES: COC(=O)c1c(N2CCOCC2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C

InChI Key: InChIKey=VKNRDBPKLZRTOR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145403   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low-density lipoprotein receptor-related protein 6


(Homo sapiens (Human))
BDBM50145403
PNG
(CHEMBL3764323)
Show SMILES COC(=O)c1c(N2CCOCC2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C
Show InChI InChI=1S/C20H21N3O6/c1-22(2)11-4-5-12-13(10-11)29-19-15(21-12)14(20(26)27-3)16(17(24)18(19)25)23-6-8-28-9-7-23/h4-5,10,25H,6-9H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.74E+3n/an/an/an/an/an/a



Aristotle University of Thessaloniki

Curated by ChEMBL


Assay Description
Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...


Bioorg Med Chem 24: 1014-22 (2016)


Article DOI: 10.1016/j.bmc.2016.01.025
BindingDB Entry DOI: 10.7270/Q2J67JRS
More data for this
Ligand-Target Pair