BDBM50145416 GSK2126458::Omipalisib
SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nccc(-c3ccnnc3)c2c1
InChI Key InChIKey=CGBJSGAELGCMKE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50145416
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.0700nMAssay Description:Inhibition of human p110delta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.510nMAssay Description:Inhibition of human p110gamma using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataKi: 0.530nMAssay Description:Inhibition of human p110beta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PI3K-gamma (unknown origin) after 40 mins by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.310nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1 peptide as substrate after 1 hr in presence of ATP by lance ultra assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.630nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 1 hr in presence of ATP by kinase-glo luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate after 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate after 1 hr in presence of ATP by kinase-glo luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 0.610nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate after 1 hr in presence of ATP by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 0.0190nMAssay Description:Competitive inhibition of human PI3K p110alpha/p85alpha using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 m...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.680nMAssay Description:Inhibition of mTOR (unknown origin) using ULight-4E-BP1(Thr37/46) peptide as substrate measured after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate incubated for 1 hr by kinase-glo luminescent assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged mTOR (1362 to end amino acids) using ULight-4E-BP1 as substrate incubated for 1 hr by LANCE Ul...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.190nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 0.440nMAssay Description:Inhibition of recombinant human full-length His-tagged PI3Kgamma expressed in baculovirus expression system using PIP2 as substrate measured after 1 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.780nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADPG...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using lipid as substrate incubated for 15 mins followed by substrate addition and measured after 60 mins ADP...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length p110alpha (1 to 1068 residues) expressed in baculovirus-infected Sf21 cells by ADP-Hunter Plus assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human GST tagged mTOR (1360 to 2549 residues) expressed in baculovirus expression system measured by LanthaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of mTOR (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Spanish National Cancer Research Centre (Cnio)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PIM1 using ARKRRRHPSGPPTA as substrate measured after 1.5 hrs by ADP hunter plus assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3K-beta (unknown origin) after 40 mins by ADP-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of mTOR kinase (unknown origin) assessed as suppression of ULight-4E-BP1 substrate phosphorylation incubated for 1 hr by lance ultra assayMore data for this Ligand-Target Pair
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)
Curated by ChEMBL
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of PI3K-delta (unknown origin) using PIP2 as substrate incubated for 1 hr by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Second Military Medical University
Curated by ChEMBL
Second Military Medical University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PI3K-alpha (unknown origin) using PIP2 as substrate incubated for 1 hr by Kinase-Glo luminescent kinase assayMore data for this Ligand-Target Pair