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BDBM50145664 CHEMBL3765403

SMILES: Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC(CNCC(O)=O)CC1)C(F)(F)F

InChI Key: InChIKey=FXJKCHJHITXJAV-JOCHJYFZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50145664   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptophan 5-hydroxylase 1


(Homo sapiens (Human))
BDBM50145664
PNG
(CHEMBL3765403)
Show SMILES Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC(CNCC(O)=O)CC1)C(F)(F)F
Show InChI InChI=1S/C24H27ClF3N7O3/c1-14-4-9-35(33-14)18-10-16(25)2-3-17(18)22(24(26,27)28)38-20-11-19(31-23(29)32-20)34-7-5-15(6-8-34)12-30-13-21(36)37/h2-4,9-11,15,22,30H,5-8,12-13H2,1H3,(H,36,37)(H2,29,31,32)/t22-/m1/s1
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MMDB

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Similars

Article
PubMed
n/an/a 5.13E+3n/an/an/an/an/an/a



Karos Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of TPH1 (unknown origin)


Bioorg Med Chem Lett 26: 1124-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.064
BindingDB Entry DOI: 10.7270/Q2WD42DJ
More data for this
Ligand-Target Pair