BDBM50146074 CHEMBL3763310

SMILES OC(=O)Cc1cnc(Nc2n[nH]c3ccc(cc23)-c2ncccc2Cl)s1

InChI Key InChIKey=WEPHZUOLCWCEHY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50146074   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146074(CHEMBL3763310)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human TYK2 kinase domain (885-1176 residues) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146074(CHEMBL3763310)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146074(CHEMBL3763310)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of JAK3 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50146074(CHEMBL3763310)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of JAK2 (unknown origin) using Ulight-JAK1 substrate peptide assessed as reduction in ATP-dependent substrate phosphorylation after 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed