BDBM50146154 KRP-114V::MK-4618::Vibegron

SMILES: [H][C@@](O)(c1ccccc1)[C@@]1([H])CC[C@@]([H])(Cc2ccc(NC(=O)[C@]3([H])CCc4nccc(=O)n34)cc2)N1

InChI Key: InChIKey=DJXRIQMCROIRCZ-UHFFFAOYSA-N

Data: 13 IC50  8 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50146154   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 1A2 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Dog)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
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Nuclear receptor subfamily 1 group I member 2 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Rhesus macaque)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	7.10	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Rat)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	122	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Rhesus macaque)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Rat)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	86	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C8 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2B6 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-2 adrenergic receptor (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-1 adrenergic receptor (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-3 adrenergic receptor (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
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Sodium-dependent serotonin transporter (Human)	BDBM50146154 (KRP-114V | MK-4618 | Vibegron) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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