BDBM50146168 ARQ-197::Tivantinib

SMILES O=C1NC(=O)[C@H]([C@@H]1c1c[nH]c2ccccc12)c1cn2CCCc3cccc1c23

InChI Key InChIKey=UCEQXRCJXIVODC-PMACEKPBSA-N

Data  2 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50146168   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of recombinant human c-Met (974 to 1390 residues) using poly-Glu-Tyr as substrate preincubated for 20 mins followed by substrate and [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataIC50:  360nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed