BDBM50146710 (S)-2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid::AMBRISENTAN::CHEMBL1111::Letairis

SMILES: Cc1cc(nc(n1)O[C@H](C(=O)O)C(c2ccccc2)(c3ccccc3)OC)C

InChI Key: InChIKey=OUJTZYPIHDYQMC-UHFFFAOYSA-N

Data: 14 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50146710   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelin-1 receptor (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelin receptor type B (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelin-1 receptor (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelin receptor type B (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelin-1 receptor (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21.7	n/a	n/a	n/a	n/a	n/a	n/a
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Endothelin receptor type B (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily D member 3 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.26E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.94E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily E/KQT member 1 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily E/KQT member 1 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor subfamily 1 group I member 2 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a
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Nuclear receptor subfamily 1 group I member 2 (Human)	BDBM50146710 (CHEMBL1111 | Letairis | (S)-2-(4,6-Dimethyl-pyrimi...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a
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