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BDBM50147296 4-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isoxazol-5-one::4-butyl-3-methyl-2-(piperidine-1-carbonyl)isoxazol-5(2H)-one::CHEMBL108207

SMILES: CCCCc1c(C)n(oc1=O)C(=O)N1CCCCC1

InChI Key: InChIKey=GRDSTXUSVGZGSQ-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50147296   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hormone-sensitive lipase (HSL)


(Homo sapiens (Human))
BDBM50147296
PNG
(4-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isox...)
Show SMILES CCCCc1c(C)n(oc1=O)C(=O)N1CCCCC1
Show InChI InChI=1S/C14H22N2O3/c1-3-4-8-12-11(2)16(19-13(12)17)14(18)15-9-6-5-7-10-15/h3-10H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant hormone sensitive lipase (HSL)


Bioorg Med Chem Lett 14: 3155-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.015
BindingDB Entry DOI: 10.7270/Q2NV9HQ5
More data for this
Ligand-Target Pair
Hormone sensitive lipase


(Homo sapiens (Human))
BDBM50147296
PNG
(4-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isox...)
Show SMILES CCCCc1c(C)n(oc1=O)C(=O)N1CCCCC1
Show InChI InChI=1S/C14H22N2O3/c1-3-4-8-12-11(2)16(19-13(12)17)14(18)15-9-6-5-7-10-15/h3-10H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant hormone sensitive lipase (HSL)


Bioorg Med Chem Lett 14: 3155-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.015
BindingDB Entry DOI: 10.7270/Q2NV9HQ5
More data for this
Ligand-Target Pair
Hormone-sensitive lipase (HSL)


(Rattus norvegicus (Rat))
BDBM50147296
PNG
(4-Butyl-3-methyl-2-(piperidine-1-carbonyl)-2H-isox...)
Show SMILES CCCCc1c(C)n(oc1=O)C(=O)N1CCCCC1
Show InChI InChI=1S/C14H22N2O3/c1-3-4-8-12-11(2)16(19-13(12)17)14(18)15-9-6-5-7-10-15/h3-10H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay


J Med Chem 51: 6478-94 (2008)


Article DOI: 10.1021/jm800718k
BindingDB Entry DOI: 10.7270/Q23778KJ
More data for this
Ligand-Target Pair