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BDBM50148718 CHEMBL332342::[4-(2,4-Difluoro-phenylamino)-phenyl]-{5-[2-(4-hydroxy-1-methyl-piperidin-4-yl)-ethyl]-2-methoxy-phenyl}-methanone

SMILES: COc1ccc(CCC2(O)CCN(C)CC2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1

InChI Key: InChIKey=VSZPVDAIEVGIFE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50148718   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase p38


(Mus musculus (mouse))
BDBM50148718
PNG
(CHEMBL332342 | [4-(2,4-Difluoro-phenylamino)-pheny...)
Show SMILES COc1ccc(CCC2(O)CCN(C)CC2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C28H30F2N2O3/c1-32-15-13-28(34,14-16-32)12-11-19-3-10-26(35-2)23(17-19)27(33)20-4-7-22(8-5-20)31-25-9-6-21(29)18-24(25)30/h3-10,17-18,31,34H,11-16H2,1-2H3
PDB
MMDB

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Similars

Article
PubMed
n/an/a 5.10E+4n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of murine His-Mitogen-activated protein kinase p38 alpha phosphorylation.


Bioorg Med Chem Lett 14: 3601-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.111
BindingDB Entry DOI: 10.7270/Q2NS0VFM
More data for this
Ligand-Target Pair