BDBM50148744 CHEMBL115253::N-(2-{3-[Bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]oct-8-yl}-ethyl)-benzamide

SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CCNC(=O)c1ccccc1)c1ccc(F)cc1

InChI Key InChIKey=CZMZTJBQMHRZQI-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50148744   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM50148744(CHEMBL115253 | N-(2-{3-[Bis-(4-fluoro-phenyl)-meth...)
Affinity DataKi:  6.46nMAssay Description:Ability of compound to inhibit dopamine uptake of receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148744(CHEMBL115253 | N-(2-{3-[Bis-(4-fluoro-phenyl)-meth...)
Affinity DataKi:  13.1nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148744(CHEMBL115253 | N-(2-{3-[Bis-(4-fluoro-phenyl)-meth...)
Affinity DataKi:  556nMAssay Description:Binding affinity at muscarinic M1 receptor in rat brain by [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148744(CHEMBL115253 | N-(2-{3-[Bis-(4-fluoro-phenyl)-meth...)
Affinity DataKi:  597nMAssay Description:Binding affinity at serotonin transporter in rat brain by [3H]-citalopram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50148744(CHEMBL115253 | N-(2-{3-[Bis-(4-fluoro-phenyl)-meth...)
Affinity DataKi:  637nMAssay Description:Displacement of [3H]nisoxetine from norepinephrine transporter (NET) of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed