BDBM50148928 CHEMBL3770909

SMILES CCNc1ncc2cc(-c3ccc(cc3Cl)-c3cncc(C)n3)c(=O)n(C[C@H]3CC[C@H](N)CC3)c2n1

InChI Key InChIKey=PJYRMGKJLXENCU-IRJFHVNHSA-N

Data  1 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50148928   

TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50148928(CHEMBL3770909)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human recombinant PAK1 kinase domain using coumarin/fluorescein-labeled FRET peptide as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50148928(CHEMBL3770909)
Affinity DataIC50:  124nMAssay Description:Inhibition of PAK1 in human EBC1 cells assessed as reduction in levels of MEK phosphorylation at S298 residue after 2 hrs by HTRF assayMore data for this Ligand-Target Pair