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BDBM50149898 CHEMBL3771269

SMILES: CCN(C1CCOCC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc[nH]c2=O)c1C

InChI Key: InChIKey=BLMJHGTVAAFFQJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50149898   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50149898
PNG
(CHEMBL3771269)
Show SMILES CCN(C1CCOCC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc[nH]c2=O)c1C
Show InChI InChI=1S/C22H28ClN3O3/c1-4-26(17-6-9-29-10-7-17)20-12-16(23)11-18(15(20)3)21(27)25-13-19-14(2)5-8-24-22(19)28/h5,8,11-12,17H,4,6-7,9-10,13H2,1-3H3,(H,24,28)(H,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Epizyme

Curated by ChEMBL


Assay Description
Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay


J Med Chem 59: 1556-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01501
BindingDB Entry DOI: 10.7270/Q2B56MM7
More data for this
Ligand-Target Pair