BDBM50150086 CHEMBL127171::[3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2-methoxy-phenoxy)-ethyl]-amine

SMILES COc1ccc(F)cc1OCCNCCCc1c[nH]c2ccc(F)cc12

InChI Key InChIKey=JVZKOTRMFQSGLN-UHFFFAOYSA-N

Data  2 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50150086   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150086([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2...)
Affinity DataEC50:  0.340nMAssay Description:Effective concentration against binding of radioligand [35S]GTP-gamma-S in CHO cells expressing human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150086([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2...)
Affinity DataKi:  1.36nMAssay Description:Binding affinity against serotonin transporter in rat cortical tissues using radioligand [3H]paroxetineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150086([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2...)
Affinity DataEC50:  4.70nMAssay Description:Effective concentration against human 5-hydroxytryptamine 1A receptor using cAMP as radioligand in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150086([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2...)
Affinity DataIC50: 20.5nMAssay Description:Inhibition concentration against [3H]5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50150086([3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(5-fluoro-2...)
Affinity DataKi:  35nMAssay Description:Binding affinity against human 5-hydroxytryptamine 1A receptor in CHO cells labeled with [3H]8-OH-DPAT radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed