BDBM50150264 CHEMBL3769817

SMILES [H][C@@]12CCC[C@]1([H])N1C(=N2)N(C)C(=O)c2c(Nc3ccccc3)n(Cc3ccc(cc3)-c3ccccn3)nc12

InChI Key InChIKey=RJKWLGFYXTZMOU-RPWUZVMVSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50150264   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  240nMAssay Description:Inhibition of recombinant full lenght human PDE4A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  300nMAssay Description:Inhibition of recombinant full lenght human PDE7B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  600nMAssay Description:Inhibition of recombinant full lenght human PDE5A using fluorescent labeled cGMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant full length human PDE3B using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of recombinant full lenght human PDE11A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of recombinant full lenght human PDE10A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  6.10E+3nMAssay Description:Inhibition of recombinant full lenght human PDE9A using fluorescent labeled cGMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  8.20E+3nMAssay Description:Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed