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BDBM50151352 5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl-thiazol-2-ylamine::5-(6-methyl-1,5-naphthyridin-4-yl)-4-(pyridin-2-yl)thiazol-2-amine::CHEMBL425177

SMILES: Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1

InChI Key: InChIKey=QXPCZCMDSKNVRW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50151352   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50151352
PNG
(5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...)
Show SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1
Show InChI InChI=1S/C17H13N5S/c1-10-5-6-13-14(21-10)11(7-9-20-13)16-15(22-17(18)23-16)12-4-2-3-8-19-12/h2-9H,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cells


J Med Chem 47: 4494-506 (2004)


Article DOI: 10.1021/jm0400247
BindingDB Entry DOI: 10.7270/Q2VQ325T
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50151352
PNG
(5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...)
Show SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1
Show InChI InChI=1S/C17H13N5S/c1-10-5-6-13-14(21-10)11(7-9-20-13)16-15(22-17(18)23-16)12-4-2-3-8-19-12/h2-9H,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of TGFR1


Eur J Med Chem 44: 4259-65 (2009)


Article DOI: 10.1016/j.ejmech.2009.07.008
BindingDB Entry DOI: 10.7270/Q2BC3ZM9
More data for this
Ligand-Target Pair
TGF-beta receptor type-1


(Homo sapiens (Human))
BDBM50151352
PNG
(5-(6-Methyl-[1,5]naphthyridin-4-yl)-4-pyridin-2-yl...)
Show SMILES Cc1ccc2nccc(-c3sc(N)nc3-c3ccccn3)c2n1
Show InChI InChI=1S/C17H13N5S/c1-10-5-6-13-14(21-10)11(7-9-20-13)16-15(22-17(18)23-16)12-4-2-3-8-19-12/h2-9H,1H3,(H2,18,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 380n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.180-0.790)


J Med Chem 47: 4494-506 (2004)


Article DOI: 10.1021/jm0400247
BindingDB Entry DOI: 10.7270/Q2VQ325T
More data for this
Ligand-Target Pair