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BDBM50151849 CHEMBL3774907

SMILES: C1CN(CCO1)c1nc(Nc2ccccc2)nc(n1)-c1cccc2[nH]ncc12

InChI Key: InChIKey=ASOLRIGVQKJPHG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50151849   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50151849
PNG
(CHEMBL3774907)
Show SMILES C1CN(CCO1)c1nc(Nc2ccccc2)nc(n1)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C20H19N7O/c1-2-5-14(6-3-1)22-19-23-18(15-7-4-8-17-16(15)13-21-26-17)24-20(25-19)27-9-11-28-12-10-27/h1-8,13H,9-12H2,(H,21,26)(H,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 800n/an/an/an/an/an/a



Sphaera Pharma Pte. Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...


ACS Med Chem Lett 6: 1190-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00322
BindingDB Entry DOI: 10.7270/Q2930W23
More data for this
Ligand-Target Pair