BDBM50152124 CHEMBL3782004

SMILES Nc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=PNMYJIOQIAEYQL-UHFFFAOYSA-N

Data  8 IC50  1 Kd  2 EC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50152124   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  7nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  5nMAssay Description:Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataEC50:  126nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  3nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using dGTP as substrate measured after 30 mins by mala...More data for this Ligand-Target Pair
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataEC50:  10nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins...More data for this Ligand-Target Pair
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataKd:  5nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant His-tagged MTH1 (unknown origin) expressed in Escherichia coli BL21(DE3) cells using dGTP as substrate incubated for 15 min...More data for this Ligand-Target Pair