BDBM50152575 2,4-Dioxo-4-o-tolyl-butyric acid::CHEMBL1829214::CHEMBL185898::Sacchettini_1

SMILES Cc1ccccc1C(=O)CC(=O)C(O)=O

InChI Key InChIKey=AVVYWVLNDGDANA-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50152575   

TargetPolymerase acidic protein(Hepatitis C virus)
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50152575(2,4-Dioxo-4-o-tolyl-butyric acid | CHEMBL1829214 |...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to PA N-terminal domain (Competitive)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50152575(2,4-Dioxo-4-o-tolyl-butyric acid | CHEMBL1829214 |...)
Affinity DataIC50:  5.45E+4nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50152575(2,4-Dioxo-4-o-tolyl-butyric acid | CHEMBL1829214 |...)
Affinity DataEC50:  6.80E+3nMAssay Description:Plaque growth inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate synthase G [C619A](Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
D3R/Abbott

LigandPNGBDBM50152575(2,4-Dioxo-4-o-tolyl-butyric acid | CHEMBL1829214 |...)
Affinity DataIC50:  1.10E+3nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys

Curated by ChEMBL
LigandPNGBDBM50152575(2,4-Dioxo-4-o-tolyl-butyric acid | CHEMBL1829214 |...)
Affinity DataIC50:  1.29E+4nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed