BDBM50152922 CHEMBL184302::N-Hydroxy-2-{1-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-cyclopentyl}-acetamide

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC2(CC(=O)NO)CCCC2)c2ccccc2n1

InChI Key InChIKey=KVMYRTIGLLQRFY-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50152922   

TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152922(CHEMBL184302 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataKi:  804nMAssay Description:Inhibition of Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152922(CHEMBL184302 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataKi:  1.51E+3nMAssay Description:Inhibition of Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152922(CHEMBL184302 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataKi:  1.57E+3nMAssay Description:inhibition of Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152922(CHEMBL184302 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataKi: >4.90E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152922(CHEMBL184302 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataIC50: <0.800nMAssay Description:Inhibition of porcine Tumor necrosis factor- alpha converting enzyme (TACE, ADAM17)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152922(CHEMBL184302 | N-Hydroxy-2-{1-[4-(2-methyl-quinoli...)
Affinity DataIC50:  420nMAssay Description:Effect on TNF-Alpha release in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed