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BDBM50153142 1-(1-Biphenyl-4-ylmethyl-piperidin-4-yl)-1,3-dihydro-benzo[1,2,5]thiadiazole 2,2-dioxide::CHEMBL187743

SMILES: O=S1(=O)Nc2ccccc2N1C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1

InChI Key: InChIKey=CKYJBUXLZYWQHH-UHFFFAOYSA-N

Data: 3 KI

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50153142   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Opioid receptors; mu/kappa/delta


(Homo sapiens (Human))
BDBM50153142
PNG
(1-(1-Biphenyl-4-ylmethyl-piperidin-4-yl)-1,3-dihyd...)
Show SMILES O=S1(=O)Nc2ccccc2N1C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H25N3O2S/c28-30(29)25-23-8-4-5-9-24(23)27(30)22-14-16-26(17-15-22)18-19-10-12-21(13-11-19)20-6-2-1-3-7-20/h1-13,22,25H,14-18H2
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PC cid
PC sid
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Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1


Bioorg Med Chem Lett 14: 5045-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.001
BindingDB Entry DOI: 10.7270/Q2TM7BV8
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50153142
PNG
(1-(1-Biphenyl-4-ylmethyl-piperidin-4-yl)-1,3-dihyd...)
Show SMILES O=S1(=O)Nc2ccccc2N1C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H25N3O2S/c28-30(29)25-23-8-4-5-9-24(23)27(30)22-14-16-26(17-15-22)18-19-10-12-21(13-11-19)20-6-2-1-3-7-20/h1-13,22,25H,14-18H2
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GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69593 binding to human Opioid receptor kappa 1


Bioorg Med Chem Lett 14: 5045-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.001
BindingDB Entry DOI: 10.7270/Q2TM7BV8
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50153142
PNG
(1-(1-Biphenyl-4-ylmethyl-piperidin-4-yl)-1,3-dihyd...)
Show SMILES O=S1(=O)Nc2ccccc2N1C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H25N3O2S/c28-30(29)25-23-8-4-5-9-24(23)27(30)22-14-16-26(17-15-22)18-19-10-12-21(13-11-19)20-6-2-1-3-7-20/h1-13,22,25H,14-18H2
PDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1


Bioorg Med Chem Lett 14: 5045-50 (2004)


Article DOI: 10.1016/j.bmcl.2004.08.001
BindingDB Entry DOI: 10.7270/Q2TM7BV8
More data for this
Ligand-Target Pair