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BDBM50153327 CHEMBL3775151

SMILES: OC(=O)c1ccncc1NCc1cccc(c1)-c1ccccc1

InChI Key: InChIKey=ILCCZYRMKZNNSG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50153327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50153327
PNG
(CHEMBL3775151)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-9-10-20-13-18(17)21-12-14-5-4-8-16(11-14)15-6-2-1-3-7-15/h1-11,13,21H,12H2,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of KDM4C (unknown origin) using H3K9Me3 peptide as substrate assessed as demethylation of substrate by Rapidfire mass spectrometric analys...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair
Lysine-specific demethylase 4C


(Homo sapiens (Human))
BDBM50153327
PNG
(CHEMBL3775151)
Show SMILES OC(=O)c1ccncc1NCc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H16N2O2/c22-19(23)17-9-10-20-13-18(17)21-12-14-5-4-8-16(11-14)15-6-2-1-3-7-15/h1-11,13,21H,12H2,(H,22,23)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of full length human HALO-tagged KDM4C expressed in human U2OS cells assessed as level of H3K9Me3 demethylation incubated overnight by Hoe...


J Med Chem 59: 1357-69 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01537
BindingDB Entry DOI: 10.7270/Q2542QFT
More data for this
Ligand-Target Pair