BDBM50153420 1N-[2-[2-(4-phenylbutyl)benzo[b]furan-4-yl]-(1R,2R)-cyclopropylmethyl]acetamide::CHEMBL186586

SMILES CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12

InChI Key InChIKey=VECIKHNMWFUKTJ-YDNXMHBPSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50153420   

TargetMelatonin receptor type 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153420(1N-[2-[2-(4-phenylbutyl)benzo[b]furan-4-yl]-(1R,2R...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of 2-[125I]-iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153420(1N-[2-[2-(4-phenylbutyl)benzo[b]furan-4-yl]-(1R,2R...)
Affinity DataKi:  10nMAssay Description:Inhibition of 2-[125I]-iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153420(1N-[2-[2-(4-phenylbutyl)benzo[b]furan-4-yl]-(1R,2R...)
Affinity DataEC50:  21nMAssay Description:Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153420(1N-[2-[2-(4-phenylbutyl)benzo[b]furan-4-yl]-(1R,2R...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed