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BDBM50154995 2-[2-(3-fluoro-5-pyridin-4-ylphenyl)-2H-tetrazol-5-yl]pyridine::CHEMBL187746

SMILES: Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccncc1

InChI Key: InChIKey=YBZAHQMKDFUBLV-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50154995   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154995
PNG
(2-[2-(3-fluoro-5-pyridin-4-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccncc1
Show InChI InChI=1S/C17H11FN6/c18-14-9-13(12-4-7-19-8-5-12)10-15(11-14)24-22-17(21-23-24)16-3-1-2-6-20-16/h1-11H
PDB
MMDB

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KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Similars

Article
PubMed
575n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50154995
PNG
(2-[2-(3-fluoro-5-pyridin-4-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccncc1
Show InChI InChI=1S/C17H11FN6/c18-14-9-13(12-4-7-19-8-5-12)10-15(11-14)24-22-17(21-23-24)16-3-1-2-6-20-16/h1-11H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 806n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against Metabotropic glutamate receptor 5 in [Ca2+] flux assay


Bioorg Med Chem Lett 14: 5485-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.016
BindingDB Entry DOI: 10.7270/Q21V5DGP
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM50154995
PNG
(2-[2-(3-fluoro-5-pyridin-4-ylphenyl)-2H-tetrazol-5...)
Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccncc1
Show InChI InChI=1S/C17H11FN6/c18-14-9-13(12-4-7-19-8-5-12)10-15(11-14)24-22-17(21-23-24)16-3-1-2-6-20-16/h1-11H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 956n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist


Bioorg Med Chem Lett 14: 5477-80 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.011
BindingDB Entry DOI: 10.7270/Q29C6WXB
More data for this
Ligand-Target Pair