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BDBM50155167 4-(6-Chloro-4-methyl-pyridazin-3-yl)-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL187323

SMILES: Cc1cc(Cl)nnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=YZCHKGKISUDFKB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155167   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50155167
PNG
(4-(6-Chloro-4-methyl-pyridazin-3-yl)-piperazine-1-...)
Show SMILES Cc1cc(Cl)nnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H17ClF3N5O/c1-11-10-14(18)23-24-15(11)25-6-8-26(9-7-25)16(27)22-13-4-2-12(3-5-13)17(19,20)21/h2-5,10H,6-9H2,1H3,(H,22,27)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay


Bioorg Med Chem Lett 14: 5513-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.010
BindingDB Entry DOI: 10.7270/Q2HX1C49
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50155167
PNG
(4-(6-Chloro-4-methyl-pyridazin-3-yl)-piperazine-1-...)
Show SMILES Cc1cc(Cl)nnc1N1CCN(CC1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H17ClF3N5O/c1-11-10-14(18)23-24-15(11)25-6-8-26(9-7-25)16(27)22-13-4-2-12(3-5-13)17(19,20)21/h2-5,10H,6-9H2,1H3,(H,22,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/a5.5n/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay


Bioorg Med Chem Lett 14: 5513-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.010
BindingDB Entry DOI: 10.7270/Q2HX1C49
More data for this
Ligand-Target Pair