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BDBM50155185 4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL185503

SMILES: FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2nncc3ccccc23)cc1

InChI Key: InChIKey=ZEGPQYHWMWQQRE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155185   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50155185
PNG
(4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-...)
Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2nncc3ccccc23)cc1
Show InChI InChI=1S/C20H18F3N5O/c21-20(22,23)15-5-7-16(8-6-15)25-19(29)28-11-9-27(10-12-28)18-17-4-2-1-3-14(17)13-24-26-18/h1-8,13H,9-12H2,(H,25,29)
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a5.5n/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assay


Bioorg Med Chem Lett 14: 5513-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.010
BindingDB Entry DOI: 10.7270/Q2HX1C49
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50155185
PNG
(4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-...)
Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2nncc3ccccc23)cc1
Show InChI InChI=1S/C20H18F3N5O/c21-20(22,23)15-5-7-16(8-6-15)25-19(29)28-11-9-27(10-12-28)18-17-4-2-1-3-14(17)13-24-26-18/h1-8,13H,9-12H2,(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Purdue Pharma LP

Curated by ChEMBL


Assay Description
Inhibition of human vanilloid receptor 1 in HEK293 cells in capsaicin-induced FLIPR assay


Bioorg Med Chem Lett 14: 5513-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.010
BindingDB Entry DOI: 10.7270/Q2HX1C49
More data for this
Ligand-Target Pair