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BDBM50155695 1-{2-Hydroxy-3-methyl-4-[2-(pyridin-4-ylsulfanyl)-benzyloxy]-phenyl}-3-methyl-butan-1-one::CHEMBL183304

SMILES: CC(C)CC(=O)c1ccc(OCc2ccccc2Sc2ccncc2)c(C)c1O

InChI Key: InChIKey=WHIFAHNILXSDGV-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50155695   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50155695
PNG
(1-{2-Hydroxy-3-methyl-4-[2-(pyridin-4-ylsulfanyl)-...)
Show SMILES CC(C)CC(=O)c1ccc(OCc2ccccc2Sc2ccncc2)c(C)c1O
Show InChI InChI=1S/C24H25NO3S/c1-16(2)14-21(26)20-8-9-22(17(3)24(20)27)28-15-18-6-4-5-7-23(18)29-19-10-12-25-13-11-19/h4-13,16,27H,14-15H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 677n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assay


Bioorg Med Chem Lett 14: 5867-72 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.028
BindingDB Entry DOI: 10.7270/Q2XW4J94
More data for this
Ligand-Target Pair