BDBM50156678 CHEMBL3792392

SMILES ONC(=O)CCCc1csc(\C=C\c2ccccc2)n1

InChI Key InChIKey=HJPIJALRLZVGMS-MDZDMXLPSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50156678   

TargetHistone deacetylase 1(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of recombinant human HDAC1 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  199nMAssay Description:Inhibition of recombinant human HDAC6 using Fluor de Lys-SIRT1 as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibition of HDAC in human HeLa cells using fluor de Lys as substrate incubated for 20 mins by microplate spectrofluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  370nMAssay Description:Inhibition of HDAC in human HeLa cells using Boc-acetyl-lysine-AMC as substrate incubated for 24 hrs by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  7.83E+4nMAssay Description:Inhibition of human recombinant HDAC10 using RHK-K(Ac)-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  1.77E+4nMAssay Description:Inhibition of full length human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/human recombinant N-terminal GST-tagged NCOR2 expressed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-K(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  567nMAssay Description:Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  2.65E+4nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC5 (657 to 1123 residues) expressed in insect cells using Boc-K(TFA)-AMC as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  1.97E+4nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in insect cells using Boc-K(TFA)-A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human recombinant C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50156678(CHEMBL3792392)
Affinity DataIC50:  3.28E+4nMAssay Description:Inhibition of human recombinant N-terminal His-tagged HDAC11 (1 to 347 residues) expressed in insect cells/baculovirus expression system using RHK-K(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed