BDBM50157562 1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one::3,3',4,4'-tetrahydroxychalcone::CHEMBL225618::US9085549, 94

SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2)cc1O

InChI Key InChIKey=DOWSJIIZLUFMFM-DAFODLJHSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50157562   

TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataKi:  1.10E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University

Curated by ChEMBL
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrotubule-associated protein tau(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataIC50:  2.14E+4nMAssay Description:The Thio S fluorometry assay as a primary screening method to identify tau protein aggregation inhibitors from our small molecule library. Aggregated...More data for this Ligand-Target Pair
In DepthDetails US Patent