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BDBM50157609 CHEMBL3785094

SMILES: COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cc(C)no3)c(=O)c2c1

InChI Key: InChIKey=LWFDHDVAJJXJRU-OAHLLOKOSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157609   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50157609
PNG
(CHEMBL3785094)
Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cc(C)no3)c(=O)c2c1
Show InChI InChI=1S/C23H22N6O4/c1-14-10-20(33-27-14)16-4-5-21-25-26-22(29(21)13-16)15(2)28-7-6-19-18(23(28)30)11-17(12-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m1/s1
PDB
MMDB

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CHEMBL
PC cid
PC sid
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Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ...


J Med Chem 59: 2328-42 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50157609
PNG
(CHEMBL3785094)
Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cc(C)no3)c(=O)c2c1
Show InChI InChI=1S/C23H22N6O4/c1-14-10-20(33-27-14)16-4-5-21-25-26-22(29(21)13-16)15(2)28-7-6-19-18(23(28)30)11-17(12-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...


J Med Chem 59: 2328-42 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01716
BindingDB Entry DOI: 10.7270/Q2SN0BVN
More data for this
Ligand-Target Pair