BDBM50158423 CHEMBL224868::N-[4-[(2-amino-6-mtehyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)thio]-2'chlorobenzoyl]-L-glutamic acid

SMILES Cc1[nH]c2nc(N)[nH]c(=O)c2c1Sc1ccc(C(=O)N[C@@H](CCC(O)=O)C(O)=O)c(Cl)c1

InChI Key InChIKey=DTVBRZFMWHDIOO-NSHDSACASA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158423   

TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50158423(CHEMBL224868 | N-[4-[(2-amino-6-mtehyl-3,4-dihydro...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50158423(CHEMBL224868 | N-[4-[(2-amino-6-mtehyl-3,4-dihydro...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50158423(CHEMBL224868 | N-[4-[(2-amino-6-mtehyl-3,4-dihydro...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed