BDBM50158460 (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone::2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran::3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone::Benzbromarone::CHEMBL388590::US20240116873, Compound Benzbromarone::US9725430, Compound 1::US9856239, benzbromarone::US9962362, Compound 1::Uroleap (TN)::cid_2333

SMILES CCc1c(c2ccccc2o1)C(=O)c3cc(c(c(c3)Br)O)Br

InChI Key InChIKey=WHQCHUCQKNIQEC-UHFFFAOYSA-N

Data  4 KI  58 IC50  2 Kd  5 EC50

PDB links: 10 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 77 hits for monomerid = 50158460   

TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKd:  15nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
6/5/2026
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TargetCytochrome P450 2C9(Human)
Washington State University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKi:  19nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
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TargetCytochrome P450 2C9(Human)
Washington State University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKi:  19nMAssay Description:Binding affinity to CYP2C9More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
1/11/2010
Entry Details Article
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TargetCytochrome P450 2C9(Human)
Washington State University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKi:  19nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
11/11/2009
Entry Details Article
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 26nMAssay Description:Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/3/2011
Entry Details Article
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 35nMAssay Description:Inhibition of human URAT1 expressed in human MDCK cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
12/3/2011
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 35nMAssay Description:Inhibition of URAT1 (unknown origin) transfected in dog MDCK cells assessed as inhibition of [14C]uric acid uptake by liquid scintillation counting m...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
3/28/2022
Entry Details Article
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TargetCytochrome P450 2C9(Human)
Washington State University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
3/29/2022
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TargetCytochrome P450 2C9(Human)
Washington State University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 41nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
3/28/2022
Entry Details Article
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TargetAldo-keto reductase family 1 member C1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 48nMAssay Description:Inhibition of 20-alpha HSD (unknown origin)More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Date in BDB:
1/11/2010
Entry Details Article
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 48nMAssay Description:Inhibition of URAT1 (unknown origin) by absorbance based assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
10/12/2025
Entry Details
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Inhibition of human URAT1 expressed in Xenopus oocytes by [14C]urate uptake assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
2/21/2021
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 120nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/19/2019
Entry Details Article
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 190nMAssay Description:Inhibition of human URAT1 expressed in Xenopus laevis oocytes assessed as inhibition of [14C]uric acid uptake measured after 60 mins by liquid scinti...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
3/28/2022
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 200nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293-A cells membrane vesicles assessed inhibition of ABCG2-mediated urate transport activi...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
6/21/2023
Entry Details
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TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKd:  200nMAssay Description:Binding affinity to thyroxin binding site of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching of intrinsic trypto...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
12/14/2024
Entry Details
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 220nMAssay Description:Inhibition of URAT1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
8/12/2021
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Inhibition of human URAT1-mediated urate uptake in HEK293 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/15/2012
Entry Details Article
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 300nMAssay Description:Inhibition of human URAT1-mediated [8-14C]uric acid uptake expressed in HEK293 cells using [8-14C]uric acid as substrate by liquid scintillation coun...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/19/2024
Entry Details
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 340nMAssay Description:Inhibition of ABCG2 (unknown origin) transfected in HEK293 cell membrane vesicle assessed as inhibition of 14C-uric acid uptake incubated for 15 mins...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
12/17/2024
Entry Details
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 390nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
6/5/2026
Entry Details PubMedPDB3D Structure (crystal)
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 530nMAssay Description:Inhibition of URAT1 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
10/12/2025
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 530nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
12/17/2024
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 550nMAssay Description:Human kidney embryonic cells HEK-293T were grown in a petri dish (diameter=10 cm) containing DMEM and 10% of bovine fetal serum culture solution, and...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
11/21/2019
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 585nMAssay Description:Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in com...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
6/29/2024
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 750nMAssay Description:URAT1 (Uric Acid Transporter 1) is expressed on the apical membrane in renal tubules. It mediates the re-uptake of uric acid from the urine into the ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
4/27/2015
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.09E+3nMAssay Description:Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in com...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
6/29/2024
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Chinese Academy of Sciences

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of his-tagged recombinant human PDE4D catalytic domain (T86 to S413 residues) expressed in Escherichia coli BL21(DE3) using [3H]-cAMP as s...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
10/13/2025
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TargetSolute carrier family 22 member 6(Human)
Southern Medical University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of OAT1 (unknown origin) transfected in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by 6-CFL add...More data for this Ligand-Target Pair

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Date in BDB:
12/17/2024
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TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKi:  2.80E+3nMMore data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLPC cidPC sidPDBSimilars

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Date in BDB:
6/5/2026
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TargetCytochrome P450 2C19(Human)
Washington State University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
Entry Details Article
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TargetMultidrug resistance-associated protein 1(Human)TBA

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Homo sapiens (human) MRP1 expressed in Sf9 cell membranes assessed as decrease in N-ethyl-maleimide-glutathione-induced inorganic phosp...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
8/31/2020
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TargetMultidrug resistance-associated protein 1(Human)TBA

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human MRP1 expressed in Spodoptera frugiperda Sf9 cells assessed as inhibition of NEM-GS-induced vanadate-sensitive ATPase activity mea...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
3/23/2012
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TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 4.26E+3nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair

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Date in BDB:
11/3/2016
Entry Details Article
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TargetSolute carrier family 22 member 6(Human)
Southern Medical University

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 4.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM) in OAT1-expressing S2 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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In Depth
Date in BDB:
8/30/2020
Entry Details Article
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TargetIsoform 2 of Nuclear receptor corepressor 2 (TRAC-1)(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 4.81E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair

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Date in BDB:
7/11/2011
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TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataEC50:  5.13E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair

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Date in BDB:
4/28/2011
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TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of acid mediated TTR V30M mutant aggregation (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by acetic bu...More data for this Ligand-Target Pair

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Date in BDB:
12/14/2024
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TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataEC50:  5.94E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair

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Date in BDB:
4/29/2011
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TargetSolute carrier family 22 member 12(Human)
University of Colorado Anschutz Medical Campus

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of URAT1 in human RPTEC assessed as inhibition of [14C]uric acid uptake preincubated for 15 mins followed by [14C]uric acid addition and i...More data for this Ligand-Target Pair

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Date in BDB:
3/28/2022
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TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 8.30E+3nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair

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Date in BDB:
6/12/2019
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TargetEyes absent homolog 3(Human)
Cincinnati Childrens Hospital Medical Center

US Patent

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 8.30E+3nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair

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Date in BDB:
3/30/2020
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TargetThyroid hormone receptor beta(Human)
University of Toyama

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataKd:  9.00E+3nMMore data for this Ligand-Target Pair

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Date in BDB:
6/5/2026
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TargetMonocarboxylate transporter 2(Rat)
Physiologisch-Chemisches Institut Der Eberhard-Karls-Universit£T T£Bingen

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 9.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair

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Date in BDB:
2/8/2013
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Target60 kDa heat shock protein, mitochondrial(Human)
Indiana University School of Medicine

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Roset...More data for this Ligand-Target Pair

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Date in BDB:
2/24/2021
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TargetEyes absent homolog 3 [223-510](Mouse)
Cincinnati Childrens Hospital Medical Center

US Patent

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+4nMAssay Description:The compounds were then tested using full-length human recombinant, purified EYA3 and pNPP as a substrate. Compounds were dissolved in DMSO and dilut...More data for this Ligand-Target Pair

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Date in BDB:
3/30/2020
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TargetEyes absent homolog 3 [223-510](Human)
Cincinnati Childrens Hospital Medical Center

US Patent

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+4nMAssay Description:An inhibitory assay was conducted using the previously described p-nitrophenylphosphate assay (Rayapureddi, J. P. et al. Nature 426, 295-298 (2003))....More data for this Ligand-Target Pair

Target InfoPDB
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Date in BDB:
6/12/2019
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TargetSphingosine 1-phosphate receptor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataEC50:  1.35E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
4/28/2011
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TargetPerilipin-1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.50E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair

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Date in BDB:
8/2/2011
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TargetBile salt export pump(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50158460(cid_2333 | Benzbromarone | 3,5-dibromo-4-hydroxyph...)Copy SMILESCopy InChI

Affinity DataIC50: 1.59E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair

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Date in BDB:
8/19/2019
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