BDBM50158531 CHEMBL3780248

SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1

InChI Key InChIKey=ARZRCJCTMNAFMV-BZSNNMDCSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50158531   

TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158531(CHEMBL3780248)
Affinity DataEC50:  2.63E+4nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158531(CHEMBL3780248)
Affinity DataEC50:  8.72E+3nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158531(CHEMBL3780248)
Affinity DataEC50:  1.57E+4nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158531(CHEMBL3780248)
Affinity DataIC50:  1.36E+4nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158531(CHEMBL3780248)
Affinity DataEC50:  1.91E+3nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute Of Pharmaceutical Education And Research

Curated by ChEMBL
LigandPNGBDBM50158531(CHEMBL3780248)
Affinity DataIC50:  2.04E+4nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed