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BDBM50158587 CHEMBL3786404

SMILES: COC[C@@H]1C[C@]11N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1

InChI Key: InChIKey=HBGOEDMOBVVGQF-BSTMIJKCNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50158587   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50158587
PNG
(CHEMBL3786404)
Show SMILES COC[C@@H]1C[C@]11N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1
Show InChI InChI=1/C21H21ClN4OS/c1-11-12(2)28-19-17(11)18(14-5-7-16(22)8-6-14)23-21(9-15(21)10-27-4)20-25-24-13(3)26(19)20/h5-8,15H,9-10H2,1-4H3/t15-,21-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<500n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Displacement of biotinylated tetra-acetylated histone H4 from His/Flag-tagged BRD4 bromodomain1 (42 to 168 residues) (unknown origin) incubated for 2...


J Med Chem 59: 1271-98 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01514
BindingDB Entry DOI: 10.7270/Q2X92D6H
More data for this
Ligand-Target Pair