BDBM50158939 5-Methyl-[2,3'']bipyridinyl::CHEMBL179589::US8609708, 46

SMILES Cc1ccc(nc1)-c1cccnc1

InChI Key InChIKey=GKRQVVOAAXTIGR-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50158939   

TargetCytochrome P450 2A6(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50158939(CHEMBL179589 | US8609708, 46 | 5-Methyl-[2,3'']bip...)
Affinity DataKi:  2.70E+3nMAssay Description:Effect on coumarin 7-hydroxylation by human Cytochrome P-450 2A6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50158939(CHEMBL179589 | US8609708, 46 | 5-Methyl-[2,3'']bip...)
Affinity DataIC50: 1.65E+4nMAssay Description:The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Human Biomolecular Research Institute

US Patent
LigandPNGBDBM50158939(CHEMBL179589 | US8609708, 46 | 5-Methyl-[2,3'']bip...)
Affinity DataIC50: 8.42E+4nMAssay Description:To gain insight into the selectivity of the synthetic compounds, nicotine, nicotine related alkaloids and nicotine metabolites for inhibition of othe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
US Patent