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BDBM50158976 CHEMBL429243::Sauvagine derivative

SMILES: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O

InChI Key: InChIKey=DBJOWHZUIIDRLV-TYXXFJLLSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50158976   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(MOUSE)
BDBM50158976
PNG
(CHEMBL429243 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C206H345N55O63S/c1-28-105(18)159(252-181(300)129(66-74-156(279)280)239-197(316)160(106(19)29-2)253-182(301)130(75-85-325-27)237-173(292)119(49-36-40-79-210)226-174(293)120(50-41-80-220-205(216)217)230-183(302)131(86-99(6)7)242-186(305)134(89-102(12)13)245-188(307)136(92-114-55-57-115(265)58-56-114)248-200(319)164(112(25)263)258-195(314)143-52-43-83-260(143)202(321)141(91-104(16)17)250-191(310)139(95-157(281)282)249-198(317)161(107(20)30-3)254-193(312)142(98-262)251-199(318)162(108(21)31-4)255-194(313)144-53-44-84-261(144)203(322)145-54-45-82-259(145)152(272)97-222-168(287)122-62-70-151(271)225-122)196(315)238-128(65-73-155(277)278)180(299)229-117(47-34-38-77-208)171(290)234-125(61-69-148(213)268)177(296)236-127(64-72-154(275)276)179(298)228-118(48-35-39-78-209)172(291)235-126(63-71-153(273)274)178(297)227-116(46-33-37-76-207)170(289)233-124(60-68-147(212)267)176(295)232-123(59-67-146(211)266)169(288)224-110(23)166(285)223-111(24)167(286)240-137(93-149(214)269)190(309)246-138(94-150(215)270)189(308)231-121(51-42-81-221-206(218)219)175(294)241-132(87-100(8)9)184(303)243-133(88-101(10)11)185(304)244-135(90-103(14)15)187(306)247-140(96-158(283)284)192(311)257-165(113(26)264)201(320)256-163(204(323)324)109(22)32-5/h55-58,99-113,116-145,159-165,262-265H,28-54,59-98,207-210H2,1-27H3,(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H2,215,270)(H,222,287)(H,223,285)(H,224,288)(H,225,271)(H,226,293)(H,227,297)(H,228,298)(H,229,299)(H,230,302)(H,231,308)(H,232,295)(H,233,289)(H,234,290)(H,235,291)(H,236,296)(H,237,292)(H,238,315)(H,239,316)(H,240,286)(H,241,294)(H,242,305)(H,243,303)(H,244,304)(H,245,307)(H,246,309)(H,247,306)(H,248,319)(H,249,317)(H,250,310)(H,251,318)(H,252,300)(H,253,301)(H,254,312)(H,255,313)(H,256,320)(H,257,311)(H,258,314)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,216,217,220)(H4,218,219,221)/t105-,106-,107-,108-,109-,110-,111-,112+,113+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-,165-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 1 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50158976
PNG
(CHEMBL429243 | Sauvagine derivative)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C206H345N55O63S/c1-28-105(18)159(252-181(300)129(66-74-156(279)280)239-197(316)160(106(19)29-2)253-182(301)130(75-85-325-27)237-173(292)119(49-36-40-79-210)226-174(293)120(50-41-80-220-205(216)217)230-183(302)131(86-99(6)7)242-186(305)134(89-102(12)13)245-188(307)136(92-114-55-57-115(265)58-56-114)248-200(319)164(112(25)263)258-195(314)143-52-43-83-260(143)202(321)141(91-104(16)17)250-191(310)139(95-157(281)282)249-198(317)161(107(20)30-3)254-193(312)142(98-262)251-199(318)162(108(21)31-4)255-194(313)144-53-44-84-261(144)203(322)145-54-45-82-259(145)152(272)97-222-168(287)122-62-70-151(271)225-122)196(315)238-128(65-73-155(277)278)180(299)229-117(47-34-38-77-208)171(290)234-125(61-69-148(213)268)177(296)236-127(64-72-154(275)276)179(298)228-118(48-35-39-78-209)172(291)235-126(63-71-153(273)274)178(297)227-116(46-33-37-76-207)170(289)233-124(60-68-147(212)267)176(295)232-123(59-67-146(211)266)169(288)224-110(23)166(285)223-111(24)167(286)240-137(93-149(214)269)190(309)246-138(94-150(215)270)189(308)231-121(51-42-81-221-206(218)219)175(294)241-132(87-100(8)9)184(303)243-133(88-101(10)11)185(304)244-135(90-103(14)15)187(306)247-140(96-158(283)284)192(311)257-165(113(26)264)201(320)256-163(204(323)324)109(22)32-5/h55-58,99-113,116-145,159-165,262-265H,28-54,59-98,207-210H2,1-27H3,(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,269)(H2,215,270)(H,222,287)(H,223,285)(H,224,288)(H,225,271)(H,226,293)(H,227,297)(H,228,298)(H,229,299)(H,230,302)(H,231,308)(H,232,295)(H,233,289)(H,234,290)(H,235,291)(H,236,296)(H,237,292)(H,238,315)(H,239,316)(H,240,286)(H,241,294)(H,242,305)(H,243,303)(H,244,304)(H,245,307)(H,246,309)(H,247,306)(H,248,319)(H,249,317)(H,250,310)(H,251,318)(H,252,300)(H,253,301)(H,254,312)(H,255,313)(H,256,320)(H,257,311)(H,258,314)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,323,324)(H4,216,217,220)(H4,218,219,221)/t105-,106-,107-,108-,109-,110-,111-,112+,113+,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,159-,160-,161-,162-,163-,164-,165-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 18n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro effective concentration for mouse corticotropin releasing factor 2 receptor


J Med Chem 48: 262-5 (2005)


Article DOI: 10.1021/jm049490m
BindingDB Entry DOI: 10.7270/Q2WH2PG5
More data for this
Ligand-Target Pair