BDBM50160870 CHEMBL3787344::US11896597, Compound EGF816::WO2022090481, Example nazartinib

SMILES: CN(C)C\C=C\C(=O)N1CCCC[C@H](C1)n1c(NC(=O)c2ccnc(C)c2)nc2cccc(Cl)c12

InChI Key: InChIKey=IOMMMLWIABWRKL-UHFFFAOYSA-N

Data: 23 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50160870   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [L858R] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [L858R,T790M,C797S] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [L858R,C797S] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [1-773,'NPH',774-1210] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	368	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	455	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-18,20-1210,C797S] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	745	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-18,20-1210,T790M] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-18,20-1210] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor/Interleukin-3 (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	505	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [1-769,'ASV',770-1210] (Human)	BDBM50160870 (CHEMBL3787344 | WO2022090481, Example nazartinib |...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	291	n/a	n/a	n/a	n/a	n/a	n/a
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