BDBM50160871 BI 1482694::HM61713::Olmutinib
SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3sccc3n2)cc1
InChI Key InChIKey=FDMQDKQUTRLUBU-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50160871
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR exon 19 deletion and L858R mutant phosphorylation in human NCI-H1975 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of wild type EGFR phosphorylation in human H358 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal GST-fused human EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labelled peptide as substrate incubated for 10 mins in presence of ATP measured by mobility s...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labelled peptide as substrate incubated for 10 mins in presence of ATP by Kinase Glo luminesc...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) using FAM-labelled peptide as substrate incubated for 10 mins fin presence of ATP by Kinase Glo lumi...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) using FAM-labelled peptide as substrate incubated for 10 mins in presence of ATP by Kinase Glo...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 9.20nMAssay Description:Inhibition of EGFR DEL19 mutant in human HCC827 cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shaanxi University Of Science & Technology
Curated by ChEMBL
Shaanxi University Of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of N-terminal GST-fused human wild type EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using 5-...More data for this Ligand-Target Pair